Engineering adjuvants for predictable immunity
نویسندگان
چکیده
منابع مشابه
Innate immunity and adjuvants
Innate immunity was for a long time considered to be non-specific because the major function of this system is to digest pathogens and present antigens to the cells involved in acquired immunity. However, recent studies have shown that innate immunity is not non-specific, but is instead sufficiently specific to discriminate self from pathogens through evolutionarily conserved receptors, designa...
متن کاملAdjuvants of Immunity
Since Jules Freund reported that crude mycobacterial extracts greatly promoted immune responses to antigens (1), the use of adjuvants has become a widespread, but poorly understood practice to promote T and B cell responses (2). Recent studies have begun to identify the chemical nature of several adjuvants and the cellular and molecular mechanisms of their long-elusive immunologi-cal effects. F...
متن کاملAdjuvants of Immunity: Harnessing Innate Immunity to Promote Adaptive Immunity
Since Jules Freund reported that crude mycobacterial extracts greatly promoted immune responses to antigens (1), the use of adjuvants has become a widespread, but poorly understood practice to promote T and B cell responses (2). Recent studies have begun to identify the chemical nature of several adjuvants and the cellular and molecular mechanisms of their long-elusive immunologi-cal effects. F...
متن کاملInnate immunity and new adjuvants.
Vaccination remains the most cost-effective biomedical approach to the control of infectious diseases in livestock. Vaccines based on killed pathogens or subunit antigens are safer but are often ineffective and require coadministration with adjuvants to achieve efficacy. Unfortunately, most conventional adjuvants are poorly defined, complex substances that fail to meet the stringent criteria fo...
متن کاملModulation of HIV-1 immunity by adjuvants
PURPOSE OF REVIEW To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments. RECENT FINDINGS Increased understanding of the role of pattern recognition receptors such as Toll-like receptors in recruiting and directing the immune system has increased the variety of adjuvant formulations...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2014
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2116insight2